Skin cells are taught to fight with brain cancer
The subtype of brain cancer - glioblastoma - is one of the most dangerous cancers. Only 30% of people with this diagnosis live longer than two years. Completely remove the tumor via surgical procedures impossible since it forms long extensions penetrating into neighboring parts of the brain. Remaining after the operation processes will soon grow, giving rise to a new tumor.
Researchers from the University of North Carolina have developed a method by which you can destroy a significant part of processes of glioblastoma. For this, they used the induced pluripotent stem cell. The technology for producing such cells has been established in 2007 by the Japanese researcher Shinya Yamanaka. In 2012, for his discovery he was awarded the Nobel Prize. Established technology allows them to transform normal cells into stem cells. Such cells may potentially be converted into any other cell types. Researchers from the University of North Carolina a little changed this technology and were able to turn the sub-type of skin cells called fibroblasts into neural stem cells.
Unlike normal stem cells, they can only be converted into neurons and glia. Experiments conducted on mice with artificially induced gliobastomoy have shown that neural stem cells have the ability to travel within the brain, to find cancer cells and cause their death. the study authors then using genetic engineering techniques introduced in these cells a gene responsible for the production of a protein that can destroy cancer cells. As a result, they were even more effective in destroying glioblastoma: the lifetime of patients laboratory animals increased by 160-220%.
In the future, this technique could be used to treat people who have had surgery to remove glioblastoma. Neural stem cells are generated from fibroblasts own patient, it can be entered in area of ??the brain from which the tumor was removed. They will be able to destroy the remnants of the tumor, which could not be overcome by surgical methods.
Researchers from the University of North Carolina have developed a method by which you can destroy a significant part of processes of glioblastoma. For this, they used the induced pluripotent stem cell. The technology for producing such cells has been established in 2007 by the Japanese researcher Shinya Yamanaka. In 2012, for his discovery he was awarded the Nobel Prize. Established technology allows them to transform normal cells into stem cells. Such cells may potentially be converted into any other cell types. Researchers from the University of North Carolina a little changed this technology and were able to turn the sub-type of skin cells called fibroblasts into neural stem cells.
Unlike normal stem cells, they can only be converted into neurons and glia. Experiments conducted on mice with artificially induced gliobastomoy have shown that neural stem cells have the ability to travel within the brain, to find cancer cells and cause their death. the study authors then using genetic engineering techniques introduced in these cells a gene responsible for the production of a protein that can destroy cancer cells. As a result, they were even more effective in destroying glioblastoma: the lifetime of patients laboratory animals increased by 160-220%.
In the future, this technique could be used to treat people who have had surgery to remove glioblastoma. Neural stem cells are generated from fibroblasts own patient, it can be entered in area of ??the brain from which the tumor was removed. They will be able to destroy the remnants of the tumor, which could not be overcome by surgical methods.